Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia

G. Howlett, Niall; Taniguchi, Toshiyasu; B. Olson, Susan; Cox, Barbara; Waisfisz, Quinten; de Die‐Smulders, Christine; S. Persky, Nicole; Grompe, Markus; Joenje, Hans; Pals, Gerard; Ikeda, Hideyuki; A. Fox, Edward; D. D’Andrea, Alan

doi:10.1126/science.1073834

Public

Biallelic Inactivation of BRCA2 in Fanconi Anemia

Published in Science • Jul 26, 2002

Authors:

Niall G. Howlett

Toshiyasu Taniguchi

Susan B. Olson

Abstract

Fanconi anemia (FA) is a rare autosomal recessive cancer susceptibility disorder characterized by cellular hypersensitivity to mitomycin C (MMC). Six FA genes have been cloned, but the gene or genes corresponding to FA subtypes B and D1 remain unidentified. Here we show that cell lines derived from ...

Subject

Fanconi anemia

Complementation

BRCA2 Protein

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