Widespread Distribution of a Newly Found Point Mutation in Voltage-Gated Sodium Channel in Pyrethroid-Resistant Aedes aegypti Populations in Vietnam

Kawada, Hitoshi; Higa, Yukiko; Komagata, Osamu; Kasai, Shinji; Tomita, Takashi; Thi Yen, Nguyen; Lee Loan, Luu; A. P. Sánchez, Rodrigo; Takagi, Masahiro

doi:10.1371/journal.pntd.0000527

Public

Widespread Distribution of a Newly Found Point Mutation in Voltage-Gated Sodium Channel in Pyrethroid-Resistant Aedes aegypti Populations in Vietnam

Published in PLoS neglected tropical diseases • Oct 5, 2009

Authors:

Hitoshi Kawada

Yukiko Higa

Osamu Komagata

Abstract

BACKGROUND: Resistance of Aedes aegypti to photostable pyrethroid insecticides is a major problem for disease-vector control programs. Pyrethroids target the voltage-gated sodium channel on the insects' neurons. Single amino acid substitutions in this channel associated with pyrethroid resistance ar...

Subject

Aedes aegypti

Knockdown resistance

Pyrethroid

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