The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

Leviel, F.; A. Hübner, Christian; Houillier, Pascal; Morla, Luciana; El Moghrabi, Soumaya; Brideau, Gaëlle; hatim, hajar; D. Parker, Mark; Kurth, Ingo; Kougioumtzes, Alexandra; Sinning, Anne; Pech, Vladimír; Riemondy, Kent; Lance Miller, R.; Hümmler, Edith; E. Shull, Gary; S. Aronson, Peter; Doucet, Alain; M. Wall, Susan; Chambrey, Régine; Eladari, Dominique

doi:10.1172/jci40145

Public

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

Published in Journal of Clinical Investigation • Apr 13, 2010

Authors:

F. Leviel

Christian A. Hübner

Pascal Houillier

Abstract

Regulation of sodium balance is a critical factor in the maintenance of euvolemia, and dysregulation of renal sodium excretion results in disorders of altered intravascular volume, such as hypertension. The amiloride-sensitive epithelial sodium channel (ENaC) is thought to be the only mechanism for ...

Subject

Bicarbonate

Reabsorption

Chemistry

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