DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?

A Roberts, Jason; K Paul, Sanjoy; Akova, Murat; Bassetti, Matteo; J De Waele, Jan; Dimopoulos, George; Kaukonen, Kirsi-Maija; Koulenti, Despoina; Martin, Claude; Montravers, Philippe; Rello, Jordi; Rhodes, Andrew; Starr, Therese; C Wallis, Steven; Lipman, Jeffrey; Study, DALI

doi:10.1093/cid/ciu027

Public

DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?

Shared by NobleBlocks on Apr 1, 2014 • 12:00 AM UTC

Authors:

Jason A Roberts

Sanjoy K Paul

Murat Akova

Abstract

BACKGROUND: Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affe...

Subject

adverse events

continuous infusion

extended infusion

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