DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current  -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

A. Roberts, Jason; K. Paul, Sanjoy; Akova, Murat; Bassetti, Matteo; J. De Waele, Jan; Dimopoulos, G.; Kaukonen, Kirsi-Maija; Koulenti, Despoina; M. Martin, Claudio; Montravers, P.; Rello, Jordi; Rhodes, Andrew; Starr, T.; C. Wallis, S.; Lipman, Jeffrey; Study, DALI; A. Roberts, Jason; Lipman, Jeffrey; Starr, T.; C. Wallis, Steven; K. Paul, Sanjoy; Margarit Ribas, A.; J. De Waele, Jan; De Crop, Luc; Spapen, Herbert; Wauters, Joost; Dugernier, Thierry; G. Jorens, Philippe; Dapper, I.; De Backer, Daniel; Silvio Taccone, Fabio; Rello, J.; Ruano, Laura; Afonso, Elsa; Álvarez-Lerma, Francisco; Gracia-Arnillas, M.P.; Fernandez, F.; de Albuquerque Pereira Feijóo, Nícolas; Bardolet, N.; Rovira, A; Garro, Pau; Colón, Diego; Castillo, C.; Fernado, J.; José López, María; Luís Fernández, José; Arribas, Alfredo; L. Teja, J.; Ots, Elsa; Carlos Montejo, Juan; S. Catalán, M.; Prieto, I.; Gonzalo, G.; Galván, Beatriz; A. Blasco, M.; Meyer, EC; Del Nogal, F.; Vidaur, Loreto; Sebastián, Rafael; M. Garde, P.; d. M. Martin Velasco, M.; Zaragoza, Rafael; Esperatti, M.; Torres, A.; Montravers, P.; Baldési, Olivier; Dupont, H.; Mahjoub, Yazine; Lasocki, Sigismond; Constantin, Jean-Michel; Payen, Jean‐François; Martin, C.; Albanèse, J.; Mallédant, Yannick; Pottecher, Julien; Yves Lefrant, Jean; Jaber, S.; Joannes-Boyau, O.; Orban, Carmen; Ostermann, Marlies; McKenzie, Cathrine; R. Berry, W.; Smith, Julie; Lei, K; Rubulotta, Francesca; Gordon, Anthony; J. Brett, Stephen; Stotz, M.; Templeton, M.; Rhodes, Andrew; Ebm, Claudia; Aparecida Moran, Cristiane; Kaukonen, K.-M.; Pettilä, Ville; Dimopoulos, G.; Koulenti, Despoina; Xristodoulou, A.; Theodorou, Vasiliki; Kouliatsis, Georgios; Sertaridou, Eleni; Anthopoulos, George; Choutas, G.; Rantis, T.; Karatzas, Stylianos; Balla, Margarita; Papanikolaou, Metaxia; Myrianthefs, Pavlos; Gavala, Alexandra; Fildisis, G.; Koutsoukou, Antonia; Kyriakopoulou, Magdalini; Petrochilou, Kalomira; Kompoti, Maria; Michalia, Martha; Clouva-Molyvdas, F.-M.; Gkiokas, George; Nikolakopoulos, F.; Psychogiou, V.; Malliotakis, Polychronis; Akoumianaki, E.; Lilitsis, Emmanuel; Koulouras, Vasilios; Nakos, George; Kalogirou, Maria; Komnos, Apostolos; Zafeiridis, Tilemachos; Chaintoutis, C.; Arvaniti, Kostoula; Matamis, Dimitris; Chaintoutis, C.; Kydona, C.; Gritsi-Gerogianni, N.; Giasnetsova, T.; Giannakou, M.; Soultati, Ioanna; Chytas, Ilias; Antoniadou, E; Antipa, E.; Lathyris, Dimitrios; Koukoubani, Triantafyllia; Paraforou, Theoniki; Spiropoulou, K.; Bekos, Vasileios; M. Spring, Alexander; Kalatzi, T.; Nikolaou, H.; Laskou, M; Strouvalis, Ioannis; Aloizos, Stavros; Kapogiannis, S.; Soldatou, O.; Bassetti, Matteo; Adembri, Chiara; Villa, Gianluca; Giarratano, Antonino; Maurizio Raineri, Santi; Cortegiani, Andrea; Montalto, Francesca; Teresa Strano, Maria; Marco Ranieri, V.; Sandroni, Claudio; De Pascale, Gennaro; Molin, Alexandre; Pelosi, Paolo; Montagnani, L.; Urbino, Rosario; Mastromauro, Ilaria; Giuseppe De Rosa, Francesco; Marco Ranieri, V.; Cardoso, Teresa; Afonso, Susana; Gonçalves-Pereira, João; P. Baptista, J.; Akova, M.; Özveren, Ahmet

doi:10.1093/cid/ciu027

Public

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Published in Clinical Infectious Diseases • Jan 14, 2014

Authors:

Jason A. Roberts

Sanjoy K. Paul

Murat Akova

Abstract

BACKGROUND: Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affe...

Subject

Medicine

Dosing

Antibiotics

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