ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors.

U, Schenk; M, Frascoli; M, Proietti; R, Geffers; E, Traggiai; J, Buer; C, Ricordi; AM, Westendorf; F, Grassi

doi:10.1126/scisignal.2001270

Public

ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors.

Shared by NobleBlocks on Mar 1, 2011 • 12:00 AM UTC

Authors:

Schenk U

Frascoli M

Proietti M

Abstract

Extracellular nucleotides are pleiotropic regulators of mammalian cell function. Adenosine triphosphate (ATP) released from CD4(+) helper T cells upon stimulation of the T cell receptor (TCR) contributes in an autocrine manner to the activation of mitogen-activated protein kinase (MAPK) signaling th...

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