ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

Schenk, Ursula; Frascoli, Michela; Proietti, Michele; Geffers, Robert; Traggiai, Elisabetta; Buer, Jan; Ricordi, Camillo; M. Westendorf, Astrid; Grassi, Fabio

doi:10.1126/scisignal.2001270

Public

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

Published in Science Signaling • Mar 1, 2011

Authors:

Ursula Schenk

Michela Frascoli

Michele Proietti

Abstract

Extracellular nucleotides are pleiotropic regulators of mammalian cell function. Adenosine triphosphate (ATP) released from CD4(+) helper T cells upon stimulation of the T cell receptor (TCR) contributes in an autocrine manner to the activation of mitogen-activated protein kinase (MAPK) signaling th...

Subject

Purinergic receptor

Cell biology

Receptor

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