Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer

Minuti, Gabriele; Cappuzzo, Federico; Duchnowska, Renata; Jassem, Jacek; Fabi, Alessandra; J. O’Brien, Terence; D. Mendoza, Adelita; Landi, Lorenza; Biernat, Wojciech; Czartoryska-Arłukowicz, Bogumiła; Jankowski, Tomasz; Zuziak, Dorota; Żok, Jolanta; Szostakiewicz, Barbara; Foszczyńska‐Kłoda, Małgorzata; Tempińska-Szałach, A; Rossi, Elisa; Varella‐Garcia, Marileila

doi:10.1038/bjc.2012.335

Public

Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer

Published in British Journal of Cancer • Jul 31, 2012

Authors:

Gabriele Minuti

Federico Cappuzzo

Renata Duchnowska

Abstract

BACKGROUND: To investigate whether copy number gain of MET or hepatocyte growth factor (HGF) affect trastuzumab sensitivity in HER2-positive metastatic breast cancer (MBC). METHODS: We analysed 130 HER2-positive MBC treated with trastuzumab-based therapy. MET and HGF gene copy numbers (GCN) were ass...

Subject

Trastuzumab

Breast cancer

Hepatocyte growth factor

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