Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance

Rao, Lang; Bu, Lin‐Lin; Xu, Junhua; Cai, Bo; Yu, Guang‐Tao; Yu, Xiaolei; He, Zhaobo; Huang, Qinqin; Li, Andrew; Guo, Shishang; Zhang, Wen‐Feng; Liu, Wei; Sun, Zhi‐Jun; Wang, Hao; Wang, Tza‐Huei; Zhao, Xingzhong

doi:10.1002/smll.201502388

Public

Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance

Published in Small • Oct 21, 2015

Authors:

Lang Rao

Lin‐Lin Bu

Junhua Xu

Abstract

For decades, poly(ethylene glycol) (PEG) has been widely incorporated into nanoparticles for evading immune clearance and improving the systematic circulation time. However, recent studies have reported a phenomenon known as "accelerated blood clearance (ABC)" where a second dose of PEGylated nanoma...

Subject

Immune system

Red blood cell

In vivo

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