Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer

Blackwell, Kimberly; J. Burstein, Harold; Maria Storniolo, Anna; S. Rugo, Hope; W. Sledge, George; Koehler, María; Ellis, Catherine; Casey, Michelle; J. Vukelja, Svetislava; Bischoff, Joachim; Baselga, José; O’Shaughnessy, Joyce

doi:10.1200/jco.2008.21.4437

Public

Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer

Published in Journal of Clinical Oncology • Feb 2, 2010

Authors:

Kimberly Blackwell

Harold J. Burstein

Anna Maria Storniolo

Abstract

PURPOSE: Preclinical studies in ErbB2-positive cell lines demonstrated a synergistic interaction between lapatinib and trastuzumab, suggesting that dual blockade is more effective than a single agent alone. EGF104900 compared the activity of lapatinib alone or in combination with trastuzumab in pati...

Subject

Lapatinib

Medicine

Trastuzumab

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!