Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Lou, Yuanmei; C. McDonald, Paul; Oloumi, Arusha; Chia, Stephen; Ostlund, Christina; Ahmadi, Ardalan; H. Kyle, Alastair; auf dem Keller, Ulrich; Leung, Samuel; Huntsman, David; Clarke, Blaise; W. Sutherland, Brent; Waterhouse, Dawn; B. Bally, Marcel; D. Roskelley, Calvin; M. Overall, Christopher; I. Minchinton, Andrew; Pacchiano, Fabio; Carta, Fabrizio; Scozzafava, Andrea; Touisni, Nadia; Winum, Jean‐Yves; T. Supuran, Claudiu; Dedhar, Shoukat

doi:10.1158/0008-5472.can-10-4261

Public

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Published in Cancer Research • Mar 17, 2011

Authors:

Yuanmei Lou

Paul C. McDonald

Arusha Oloumi

Abstract

Carbonic anhydrase IX (CAIX) is a hypoxia and HIF-1-inducible protein that regulates intra- and extracellular pH under hypoxic conditions and promotes tumor cell survival and invasion in hypoxic microenvironments. Interrogation of 3,630 human breast cancers provided definitive evidence of CAIX as an...

Subject

Metastasis

Cancer research

Breast cancer

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