Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

J. McLaren, Paul; Coulonges, Cedric; Bartha, István; L. Lenz, Tobias; J. Deutsch, Aaron; Bashirova, Arman; Buchbinder, Susan; N. Carrington, Mary; Cossarizza, Andrea; Dalmau, Judith; De Luca, Andrea; J. Goedert, James; Gurdasani, Deepti; W. Haas, David; T. Herbeck, Joshua; O. Johnson, Eric; D. Kirk, Gregory; Lambotte, Olivier; Luo, Ma; Mallal, Simon; van Manen, Daniëlle; Martinez-Picado, Javier; Meyer, Laurence; M. Miro, José; I. Mullins, James; Obel, Niels; Poli, Guido; S. Sandhu, Manjinder; Schuitemaker, Hanneke; R. Shea, Patrick; Theodorou, Ioannis; D. Walker, Bruce; C. Weintrob, Amy; A. Winkler, Cheryl; M. Wolinsky, Steven; Raychaudhuri, Soumya; B. Goldstein, David; Telenti, Amalio; I. W. de Bakker, Paul; Zagury, Jean-François; Fellay, Jacques

doi:10.1073/pnas.1514867112

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Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

Shared by NobleBlocks on Nov 9, 2015 • 12:00 AM UTC

Authors:

Paul J. McLaren

Cedric Coulonges

István Bartha

Abstract

Significance A proportion of the variation in HIV-1 viral load in the infected population is influenced by host genetics. Using a large sample of infected individuals ( n = 6,315) with genome-wide genotype data, we sought to map genomic regions that influence HIV viral load and quantify their impact...

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