Immortalization of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins

D. Ramirez, Ruben; Sheridan, Shelley; Girard, Luc; Sato, Mitsuo; Kim, Young; Pollack, Jon; Peyton, Michael; Zou, Ying; M. Kurie, Jonathan; Michael DiMaio, J.; Milchgrub, Sara; L. Smith, Alice; F. Souza, Rhonda; Gilbey, Laura; Zhang, Xi; Gandia, Kenia; B. Vaughan, Melville; E. Wright, Woodring; F. Gazdar, Adi; W. Shay, Jerry; D. Minna, John

doi:10.1158/0008-5472.can-04-3703

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Immortalization of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins

Shared by NobleBlocks on Dec 15, 2004 • 12:00 AM UTC

Authors:

Ruben D. Ramirez

Shelley Sheridan

Luc Girard

Abstract

Abstract By expressing two genes (hTERT and Cdk4), we have developed a method to reproducibly generate continuously replicating human bronchial epithelial cell (HBEC) lines that provide a novel resource to study the molecular pathogenesis of lung cancer and the differentiation of bronchial epithelia...

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