Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

Hickson, Ian; Zhao, Yan; J. Richardson, Caroline; J. Green, Sharon; M.B. Martin, Niall; I. Orr, Alisdair; M. Reaper, Philip; P. Jackson, Stephen; J. Curtin, Nicola; C.M. Smith, Graeme

doi:10.1158/0008-5472.can-04-2727

Public

Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

Published in Cancer Research • Dec 15, 2004

Authors:

Ian Hickson

Yan Zhao

Caroline J. Richardson

Abstract

The serine/threonine protein kinase ATM signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p53, CHK2, NBS1, and BRCA1. Mutation of ATM occurs in the human autosomal recessive disorder ataxia-telangiectasia, which is characterized by hypersensitivity to ioni...

Subject

Kinase

DNA damage

Ataxia-telangiectasia

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