Phase I Study of GSK461364, a Specific and Competitive Polo-like Kinase 1 Inhibitor, in Patients with Advanced Solid Malignancies

Olmos, David; S. Barker, Douglas; Sharma, Rohini; T. Brunetto, André; A. Yap, Timothy; B. Taegtmeyer, Anne; Barriuso, Jorge; Medani, Hanine; Degenhardt, Yan; J. Allred, Alicia; A. Smith, Deborah; C. Murray, Sharon; A. Lampkin, Thomas; M. Dar, Mohammed; H. Wilson, Richard; S. de Bono, Johann; P. Blagden, Sarah

doi:10.1158/1078-0432.ccr-10-2946

Public

Phase I Study of GSK461364, a Specific and Competitive Polo-like Kinase 1 Inhibitor, in Patients with Advanced Solid Malignancies

Published in Clinical Cancer Research • Apr 2, 2011

Authors:

David Olmos

Douglas S. Barker

Rohini Sharma

Abstract

PURPOSE: GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1). A phase I study of two schedules of intravenous GSK461364 was conducted. EXPERIMENTAL DESIGN: GSK461364 was administered in escalating doses to patients with solid malignancies by two schedules, either on days 1, 8, and...

Subject

Medicine

Neutropenia

Pharmacokinetics

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