Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

B. Goldfine, Allison; Silver, Robert; Aldhahi, Waleed; Cai, Dongsheng; Tatro, Elizabeth; Lee, Jongsoon; E. Shoelson, Steven

doi:10.1111/j.1752-8062.2008.00026.x

Public

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

Published in Clinical and Translational Science • May 1, 2008

Authors:

Allison B. Goldfine

Robert Silver

Waleed Aldhahi

Abstract

OBJECTIVES: Chronic subacute inflammation is implicated in the pathogenesis of insulin resistance and type 2 diabetes. Salicylates were shown years ago to lower glucose and more recently to inhibit NF-kappaB activity. Salsalate, a prodrug form of salicylate, has seen extensive clinical use and has a...

Subject

Medicine

Insulin resistance

Type 2 diabetes

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