Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in <i>ob/ob</i> mice

Bouhidel, Omar; Pons, Sandrine; Souktani, R.; Zini, Roland; Berdeaux, Alain; Ghaleh, Bijan

doi:10.1152/ajpheart.00379.2008

Public

Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice

Published in American Journal of Physiology-Heart and Circulatory Physiology • Aug 9, 2008

Authors:

Omar Bouhidel

Sandrine Pons

R. Souktani

Abstract

Ischemic postconditioning (IPCD) significantly reduces infarct size in healthy animals and protects the human heart. Because obesity is a major risk factor of cardiovascular diseases, the effects of IPCD were investigated in 8- to 10-wk-old leptin-deficient obese (ob/ob) mice and compared with wild-...

Subject

Ischemia

Cardiology

Internal medicine

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