Analysis of embCAB Mutations Associated with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Isolates from China

Zhao, Lili; Sun, Qing; Liu, Haican; Wu, Xiaocui; Xiao, Tongyang; Zhao, Xiu-qin; Li, Guilian; Jiang, Yi; Zeng, Chunyan; Wan, Kanglin

doi:10.1128/aac.04933-14

Public

Analysis of embCAB Mutations Associated with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Isolates from China

Published in Antimicrobial Agents and Chemotherapy • Jan 20, 2015

Authors:

Lili Zhao

Qing Sun

Haican Liu

Abstract

Ethambutol (EMB) plays a pivotal role in the chemotherapy of drug-resistant tuberculosis (TB), including multidrug-resistant tuberculosis (MDR-TB). Resistance to EMB is considered to be caused by mutations in the embCAB operon (embC, embA, and embB). In this study, we analyzed the embCAB mutations a...

Subject

Ethambutol

Mycobacterium tuberculosis

Biology

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