Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus

C. Wen, C.; Kuo, Yueh‐Hsiung; Jan, Jia-Tsrong; Liang, Po‐Huang; Wang, Sheng‐Yang; Liu, Hong-Gi; Lee, Ching‐Kuo; Chang, Shang‐Tzen; Kuo, Chih‐Jung; Lee, Shoei‐Sheng; Hou, Chia-Chung; Hsiao, Pei‐Wen; Chien, Shih-Chang; Shyur, Lie‐Fen; Yang, Ning-Sun

doi:10.1021/jm070295s

Public

Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus

Published in Journal of Medicinal Chemistry • Jul 31, 2007

Authors:

C. C. Wen

Yueh‐Hsiung Kuo

Jia-Tsrong Jan

Abstract

In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and ...

Subject

Vero cell

Chemistry

Terpenoid

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