A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells

K. Datta, Sandip; Redecke, Vanessa; R. Prilliman, Kiley; Takabayashi, Kenji; Corr, Maripat; C. Tallant, Thomas; DiDonato, Joseph; Dziarski, Roman; Akira, Shizuo; P. Schoenberger, Stephen; Raz, Eyal

doi:10.4049/jimmunol.170.8.4102

Public

A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells

Published in The Journal of Immunology • Apr 1, 2003

Authors:

Sandip K. Datta

Vanessa Redecke

Kiley R. Prilliman

Abstract

Dendritic cells (DCs) are capable of cross-presenting exogenous Ag to CD8(+) CTLs. Detection of microbial products by Toll-like receptors (TLRs) leads to activation of DCs and subsequent orchestration of an adaptive immune response. We hypothesized that microbial TLR ligands could activate DCs to cr...

Subject

Cross-presentation

TLR9

TLR3

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