Convergent genetic and expression data implicate immunity in Alzheimer's disease

Jones, Lesley; Lambert, Jean‐Charles; Wang, Weixin; Choi, Seung‐Hoan; Harold, Denise; Vedernikov, Alexey; Escott‐Price, Valentina; Stone, Timothy; Richards, Alexander; Bellenguez, Céline; A. Ibrahim‐Verbaas, Carla; C. Naj, Adam; Sims, Rebecca; Gerrish, Amy; Jun, Gyungah; L. DeStefano, Anita; C. Bis, Joshua; W. Beecham, Gary; Grenier‐Boley, Benjamin; Russo, Giancarlo; A. Thornton‐Wells, Tricia; Jones, Nicola; V. Smith, Albert; Chouraki, Vincent; Thomas, Charlene; Arfan Ikram, M.; Zélénika, Diana; N. Vardarajan, Badri; Kamatani, Yoichiro; Lin, Chiao‐Feng; Schmidt, Helena; W. Kunkle, Brian; Dunstan, Melanie; Ruiz, Agustı́n; Bihoreau, Marie‐Thérèse; Reitz, Christiane; Pasquier, Florence; Hollingworth, Paul; Hanon, Olivier; L. Fitzpatrick, Annette; D. Buxbaum, Joseph; Campion, Dominique; K. Crane, Paul; Becker, Tim; Guðnason, Vilmundur; Cruchaga, Carlos; W. Craig, David; Amin, Najaf; Berr, Claudine; L. López, Oscar; L. De Jager, Philip; Deramecourt, Vincent; Johnston, Janet; A. Evans, Denis; Lovestone, Simon; Letteneur, Luc; Kornhuber, Johanes; Tárraga, Lluís; C. Rubinsztein, David; Eiriksdottir, Gudny; Sleegers, Kristel; Goate, Alison; Fiévet, Nathalie; J. Huentelman, Matthew; Gill, Michael; Emilsson, Valur; Brown, Kristelle; Ilyas Kamboh, M.; Keller, Lina; Barberger‐Gateau, Pascale; McGuinness, Bernadette; B. Larson, Eric; Myers, Amanda; Dufouil, Carole; Todd, Stephen; Wallon, David; Love, Seth; G. Kehoe, Patrick; Rogaeva, Ekaterina; Gallacher, John; St George‐Hyslop, Peter; Clarimón, Jordi; Lleὀ, Alberti; Bayer, Anthony; W. Tsuang, Debby; Yu, Lei; Tsolaki, Magda; Bossù, Paola; Spalletta, Gianfranco; Proitsi, Petra; Collinge, John; Sorbi, Sandro; Sánchez-García, Florentino; C. Fox, Nick; Hardy, John; Cándida Déniz Naranjo, María; Razquín, Cristina; Bosco, Paola; Clarke, Robert; Brayne, Carol; Galimberti, Daniela; Mancuso, Michelangelo; CFAS, MRC; Moebus, Susanne; Mecocci, Patrizia; Del Zompo, Maria; Maier, Wolfgang; Hampel, Harald; Pilotto, Alberto; J. Bullido, María; Panza, Francesco; Caffarra, Paolo; Nacmias, Benedetta; R. Gilbert, John; Mayhaus, Manuel; Jessen, Frank; Dichgans, Martin; Lannfelt, Lars; Håkonarson, Håkon; Pichler, Sabrina; M. Carrasquillo, Minerva; Ingelsson, Martin; Beekly, Duane; Alavarez, Victoria; Zou, Fanggeng; Valladares, Otto; G. Younkin, Steven; Coto, Eliécer; L. Hamilton‐Nelson, Kara; Mateo, Ignacio; J. Owen, Michael; M. Faber, Kelley; V. Jónsson, Pálmi; Combarros, Onofre; O‘Donovan, Michael; B. Cantwell, Laura; Soininen, Hilkka; Blacker, Deborah; Mead, Simon; H. Mosley, Thomas; Bennett, David; B. Harris, Tamara; Fratiglioni, Laura; Holmes, Clive; F.A.G. de Bruijn, Renée; Passmore, Peter; J. Montine, Thomas; Bettens, Karolien; I. Rotter, Jerome; Brice, Alexis; Morgan, Kevin; Foroud, Tatiana; A. Kukull, Walter; Hannequin, Didier; Powell, John; A. Nalls, Michael; Ritchie, Karen; L. Lunetta, Kathryn; S.K. Kauwe, John; Boerwinkle, Eric; Riemenschneider, Matthias; Boada, Merçé; Hiltunen, Mikko; R. Martin, Eden; Pástor, Pau; Schmidt, Reinhold; Rujescu, Dan; Dartigues, Jean‐François; Mayeux, Richard; Tzourio, Christophe; Hofman, Albert; M. Nöthen, Markus; Graff, Caroline; M. Psaty, Bruce; L. Haines, Jonathan; Lathrop, Mark; A. Pericak‐Vance, Margaret; J. Launer, Lenore; A. Farrer, Lindsay; M. van Duijn, Cornelia; Van Broeckhoven, Christine; Ramı́rez, Alfredo; D. Schellenberg, Gerard; Seshadri, Sudha; Amouyel, Philippe; Williams, Julie; Holmans, Peter

doi:10.1016/j.jalz.2014.05.1757

Public

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Published in Alzheimer s & Dementia • Dec 19, 2014

Authors:

Lesley Jones

Jean‐Charles Lambert

Weixin Wang

Abstract

BACKGROUND: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. METHODS: The ALIGATOR and GSEA...

Subject

Biology

Genome-wide association study

Disease

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