Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

P. O’Connell, Michael; Marchbank, Katie; R. Webster, Marie; A. Valiga, Alexander; Kaur, Amanpreet; Vultur, Adina; Li, Ling; Herlyn, Meenhard; Villanueva, Jessie; Liu, Qin; Yin, Xiangfan; Widura, Sandy; L. Nelson, Janelle; Ruiz, Nivia; C. Camilli, Tura; E. Indig, Fred; T. Flaherty, Keith; A. Wargo, Jennifer; T. Frederick, Dennie; A. Cooper, Zachary; Nair, Suresh; K. Amaravadi, Ravi; M. Schuchter, Lynn; C. Karakousis, Giorgos; Xu, Wei; Xu, Xiaowei; T. Weeraratna, Ashani

doi:10.1158/2159-8290.cd-13-0005

Public

Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Published in Cancer Discovery • Oct 9, 2013

Authors:

Michael P. O’Connell

Katie Marchbank

Marie R. Webster

Abstract

UNLABELLED: An emerging concept in melanoma biology is that of dynamic, adaptive phenotype switching, where cells switch from a highly proliferative, poorly invasive phenotype to a highly invasive, less proliferative one. This switch may hold significant implications not just for metastasis, but als...

Subject

Melanoma

Cancer research

Wnt signaling pathway

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