Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes

The fully active dihydroxylated metabolite of vitamin D3 induces the expression ofCYP3A4 and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human hepatocytes. Electrophoretic mobility shift assays and cotransfection in HepG2 cells using wild-type and mutated oligonucleo... View More