Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Jho, Eek‐hoon; Zhang, Tong; Domon–Dell, Claire; Joo, Choun‐Ki; Freund, Jean‐Noël; Costantini, Frank

doi:10.1128/mcb.22.4.1172-1183.2002

Public

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Published in Molecular and Cellular Biology • Feb 1, 2002

Authors:

Eek‐hoon Jho

Tong Zhang

Claire Domon–Dell

Abstract

Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the phosphorylation and degradation of beta-catenin. While Axin is expressed ubiquitously, Axin2 mRNA was seen in a restricted pattern during mouse embryogenesis and organogenesis. Because ...

Subject

AXIN2

Biology

Wnt signaling pathway

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