Crenolanib Inhibits the Drug-Resistant PDGFRA D842V Mutation Associated with Imatinib-Resistant Gastrointestinal Stromal Tumors

C. Heinrich, Michael; Griffith, Diana; McKinley, Arin; Patterson, Janice; Presnell, Ajia; Ramachandran, Abhijit; Dêbiec‐Rychter, Maria

doi:10.1158/1078-0432.ccr-12-0625

Public

Crenolanib Inhibits the Drug-Resistant PDGFRA D842V Mutation Associated with Imatinib-Resistant Gastrointestinal Stromal Tumors

Published in Clinical Cancer Research • Jun 28, 2012

Authors:

Michael C. Heinrich

Diana Griffith

Arin McKinley

Abstract

PURPOSE: To determine the potential of crenolanib, a potent inhibitor of PDGFRA, to treat malignancies driven by mutant PDGFRA. EXPERIMENTAL DESIGN: The biochemical activity of crenolanib was compared with imatinib using a panel of PDGFRA-mutant kinases expressed in several different cell line model...

Subject

PDGFRA

Imatinib

Cancer research

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