Stratification of Wilms tumor by genetic and epigenetic analysis.

H Scott, Richard; Murray, Anne; Baskcomb, Linda; Turnbull, Clare; Loveday, Chey; Al-Saadi, Reem; Williams, Richard; Breatnach, Fin; Gerrard, Mary; Hale, Juliet; Kohler, Janice; Lapunzina, Pablo; A Levitt, Gill; Picton, Sue; Pizer, Barry; D Ronghe, Milind; Traunecker, Heidi; Williams, Denise; Kelsey, Anna; M Vujanic, Gordan; J Sebire, Neil; Grundy, Paul; A Stiller, Charles; Pritchard-Jones, Kathy; Douglas, Jenny; Rahman, Nazneen

doi:10.18632/oncotarget.468

Public

Stratification of Wilms tumor by genetic and epigenetic analysis.

Shared by NobleBlocks on Mar 1, 2012 • 12:00 AM UTC

Authors:

Richard H Scott

Anne Murray

Linda Baskcomb

Abstract

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we analysed all five loci in 120 Wilms tumors. We identified epigenetic 11p15 abnormalities in 69% of tumors, 37% were H19 epimutat...

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