Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration

J. Walsh, Thomas; O. Karlsson, Mats; Driscoll, Timothy; Arguedas, Adriano; C. Adamson, Peter; Sáez‐Llorens, Xavier; Vora, Ajay; Arrieta, Antonio; L. Blumer, Jeffrey; Lutsar, Irja; A. Milligan, Peter; Wood, Nolan

doi:10.1128/aac.48.6.2166-2172.2004

Public

Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration

Published in Antimicrobial Agents and Chemotherapy • May 21, 2004

Authors:

Thomas J. Walsh

Mats O. Karlsson

Timothy Driscoll

Abstract

We conducted a multicenter study of the safety, tolerability, and plasma pharmacokinetics of the parenteral formulation of voriconazole in immunocompromised pediatric patients (2 to 11 years old). Single doses of 3 or 4 mg/kg of body weight were administered to six and five children, respectively. I...

Subject

Pharmacokinetics

Voriconazole

Medicine

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