The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

P. Briscoe, Celia; Tadayyon, Mohammad; L. Andrews, John; G. Benson, William; Chambers, Jon; M. Eilert, Michelle; Ellis, Catherine; A. Elshourbagy, Nabil; S. Goetz, Aaron; T. Minnick, Dana; R. Murdock, Paul; R. Sauls, Howard; Shabon, Usman; D. Spinage, Lisa; C. Strum, Jay; Szekeres, Philip; B. Tan, K.; M. Way, James; M. Ignar, Diane; Wilson, Shelagh; I. Muir, Alison

doi:10.1074/jbc.m211495200

Public

The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

Published in Journal of Biological Chemistry • Mar 1, 2003

Authors:

Celia P. Briscoe

Mohammad Tadayyon

John L. Andrews

Abstract

GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed. Ligand fishing experiments in HEK293 cells expressing human GPR40 revealed that a range of saturated and unsaturated carboxylic acids with car...

Subject

Free fatty acid receptor 1

Receptor

Ligand (biochemistry)

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