A biomimetic motility assay provides insight into the mechanism of actin-based motility

Wiesner, Sebastian; Helfer, Emmanuèle; Didry, Dominique; Ducouret, Guylaine; Lafuma, Françoise; Carlier, Marie-France; Pantaloni, Dominique

doi:10.1083/jcb.200207148

Public

A biomimetic motility assay provides insight into the mechanism of actin-based motility

Published in The Journal of Cell Biology • Jan 27, 2003

Authors:

Sebastian Wiesner

Emmanuèle Helfer

Dominique Didry

Abstract

Abiomimetic motility assay is used to analyze the mechanism of force production by site-directed polymerization of actin. Polystyrene microspheres, functionalized in a controlled fashion by the N-WASP protein, the ubiquitous activator of Arp2/3 complex, undergo actin-based propulsion in a medium tha...

Subject

Protein filament

Actin

Biophysics

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