Inhibition of Macrophage Migration Inhibitory Factor or Its Receptor (CD74) Attenuates Growth and Invasion of DU-145 Prostate Cancer Cells

L. Meyer‐Siegler, Katherine; A. Iczkowski, Kenneth; Leng, Lin; Bucala, Richard; L. Vera, Pedro

doi:10.4049/jimmunol.177.12.8730

Public

Inhibition of Macrophage Migration Inhibitory Factor or Its Receptor (CD74) Attenuates Growth and Invasion of DU-145 Prostate Cancer Cells

Published in The Journal of Immunology • Dec 1, 2006

Authors:

Katherine L. Meyer‐Siegler

Kenneth A. Iczkowski

Lin Leng

Abstract

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is overexpressed in prostate cancer, but the mechanism by which MIF exerts effects on tumor cells remains undetermined. MIF interacts with its identified membrane receptor, CD74, in association with CD44, resulting in ERK 1/2 ...

Subject

Macrophage migration inhibitory factor

Prostate cancer

LNCaP

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