Hepatic Iron Overload Induces Hepatocellular Carcinoma in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein

Furutani, Takakazu; Hino, Keisuke; Okuda, Michiari; Gondo, Toshikazu; Nishina, Sohji; Kitase, Akira; Korenaga, Masaaki; Xiao, Shu‐Yuan; A. Weinman, Steven; M. Lemon, Stanley; Sakaida, Isao; Okita, Kiwamu

doi:10.1053/j.gastro.2006.02.060

Public

Hepatic Iron Overload Induces Hepatocellular Carcinoma in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein

Published in Gastroenterology • Jun 1, 2006

Authors:

Takakazu Furutani

Keisuke Hino

Michiari Okuda

Abstract

BACKGROUND & AIMS: Despite the evidence of hepatic iron overload in patients with chronic hepatitis C, it remains unknown if iron overload is related to hepatocarcinogenesis in this condition. The aim of this study was to determine whether iron overload contributes to development of hepatocellular c...

Subject

Hepatocellular carcinoma

Steatosis

Genetically modified mouse

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