A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis

Belfort, Renata; A. Harrison, Stephen; Brown, Kenneth; Darland, Celia; Finch, Joan; Hardies, Jean; Balas, Bogdan; Gastaldelli, Amalia; O. Tio, Fermin; P. Pulcini, Joseph; Berria, Rachele; Jennie, Z.; Kumar Dwivedi, Sunil; Havranek, Russell; Fincke, Chris; A. DeFronzo, Ralph; A. Bannayan, George; Schenker, Steven; Cusi, Kenneth

doi:10.1056/nejmoa060326

Public

A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis

Published in New England Journal of Medicine • Nov 29, 2006

Authors:

Renata Belfort

Stephen A. Harrison

Kenneth Brown

Abstract

BACKGROUND: No pharmacologic therapy has conclusively proved to be effective for the treatment of nonalcoholic steatohepatitis, which is characterized by insulin resistance, steatosis, and necroinflammation with or without centrilobular fibrosis. Pioglitazone is a thiazolidinedione that ameliorates ...

Subject

Pioglitazone

Internal medicine

Medicine

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