Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine

Venkatesan, Meera; B. Gadalla, Nahla; Stepniewska, Kasia; Dahal, Prabin; Nsanzabana, Christian; Moriera, Clarissa; N. Price, Ric; Mårtensson, Andreas; J. Rosenthal, Philip; Dorsey, Grant; J. Sutherland, Colin; J. Guérin, Philippe; M. E. Davis, Timothy; Ménard, Didier; Adam, Ishag; Ademowo, George; Arze, Cesar; N. Baliraine, Frederick; Berens‐Riha, Nicole; Björkman, Anders; Borrmann, Steffen; Checchi, Francesco; Desai, Meghna; Dhorda, Mehul; Djimdé, Abdoulaye; El-Sayed, Badria; Eshetu, Teferi; Eyase, Frederick; O. Falade, Catherine; Faucher, Jean‐François; Fröberg, Gabrielle; Grivoyannis, Anastasia; Hamour, Sally; Houzé, Sandrine; D. Johnson, Jacob; Kamugisha, Erasmus; Kariuki, Simon; Kiechel, Jean‐René; Kironde, Fred; Kofoed, Poul‐Erik; Lebras, J; Malmberg, Maja; Mwai, Leah; Ngasala, Billy; Nosten, François; L. Nsobya, Samuel; Nzila, Alexis; C. Oguike, Mary; Dahlström Otienoburu, Sabina; Ogutu, Bernhards; Ouédraogo, Jean‐Bosco; Piola, Patrice; Rombo, Lars; Schramm, Birgit; Fabrice Somé, Anyirékun; Thwing, Julie; Ursing, Johan; P. M. Wong, Rina; Zeynudin, Ahmed; Zongo, Issaka; V. Plowe, Christopher; Hopkins Sibley, Carol; _, _

doi:10.4269/ajtmh.14-0031

Public

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine

Published in American Journal of Tropical Medicine and Hygiene • Jul 22, 2014

Authors:

Meera Venkatesan

Nahla B. Gadalla

Kasia Stepniewska

Abstract

Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with de...

Subject

Amodiaquine

Plasmodium falciparum

Malaria

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