Common variants in CASP3 confer susceptibility to Kawasaki disease

Onouchi, Yoshihiro; Ozaki, Kouichi; C. Buns, Jane; Shimizu, Chisato; Hamada, Hiromichi; Honda, Takafumi; Terai, Masaru; Honda, Akihito; Takeuchi, Takashi; Shibuta, Shoichi; Suenaga, Tomohiro; Suzuki, Hiroyuki; Higashi, Kouji; Yasukawa, Kumi; Suzuki, Yoichi; Sasago, Kumiko; Kemmotsu, Yasushi; Takatsuki, Shinichi; Saji, Tsutomu; Yoshikawa, Tetsushi; Nagai, Toshiro; Hamamoto, Kunihiro; Kishi, Fumio; Ouchi, Kazunobu; Sato, Yoshitake; W. Newburger, Jane; Baker, Annette; T. Shulman, Stanford; H. Rowley, Anne; Yashiro, Mayumi; Nakamura, Yoshikazu; Wakui, Keiko; Fukushima, Yoshimitsu; Fujino, Akihiro; Tsunoda, Tatsuhiko; Kawasaki, Tomisaku; Hata, Akira; Nakamura, Yusuke; Tanaka, Toshihiro

doi:10.1093/hmg/ddq176

Public

Common variants in CASP3 confer susceptibility to Kawasaki disease

Published in Human Molecular Genetics • Apr 27, 2010

Authors:

Yoshihiro Onouchi

Kouichi Ozaki

Jane C. Buns

Abstract

Kawasaki disease (KD; OMIM 611775) is an acute vasculitis syndrome which predominantly affects small- and medium-sized arteries of infants and children. Epidemiological data suggest that host genetics underlie the disease pathogenesis. Here we report that multiple variants in the caspase-3 gene (CAS...

Subject

Biology

Linkage disequilibrium

SNP

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