IL-33 is a crucial amplifier of innate rather than acquired immunity

Oboki, Keisuke; Ohno, Tatsukuni; Kajiwara, Naoki; Arae, Ken; Morita, Hideaki; Ishii, Akina; Nambu, Aya; Abe, Takaya; Kiyonari, Hiroshi; Matsumoto, Kenji; Sudo, Katsuko; Okumura, Ko; Saito, Hirohisa; Nakae, Susumu

doi:10.1073/pnas.1003059107

Public

IL-33 is a crucial amplifier of innate rather than acquired immunity

Published in Proceedings of the National Academy of Sciences • Oct 11, 2010

Authors:

Keisuke Oboki

Tatsukuni Ohno

Naoki Kajiwara

Abstract

IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that is especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been suggested to act as an "alarmin" that amplifies immune responses during tissue injury. In contrast to IL-1, however...

Subject

Immunology

Immune system

Interleukin 33

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