Genome-wide association analysis identifies multiple loci related to resting heart rate

Eijgelsheim, M.; Newton-Cheh, Chris; Sotoodehnia, N.; I. W. de Bakker, Paul; Muller, M.; C. Morrison, Alanna; V. Smith, Albert; Isaacs, Aaron; Sanna, Serena; Dörr, Marcus; Navarro, Pau; Fuchsberger, Christian; Nolte, I; J. C. de Geus, Eco; Estrada, Karol; Hwang, Shih‐Jen; Bis, Josh; Ruckert, I.-M.; Alonso, Álvaro; J. Launer, L.; J. Hottenga, J.; Rivadeneira, Fernando; A. Noseworthy, Peter; Rice, Kenneth; Perz, Siegfried; E. Arking, Dan; D. Spector, T.; A. Kors, Jan; S. Aulchenko, Yurii; V. Tarasov, Kirill; Homuth, Georg; Wild, SH; Marroni, Fabio; Gieger, Christian; M.M. Licht, Carmilla; J. Prineas, Ronald; Hofman, Albert; I. Rotter, Jerome; A. Hicks, Andrew; Ernst, Florian; S. Najjar, Samer; Wright, A.F.; Peters, Annette; R. Fox, Ervin; A. Oostra, Ben; K Kroemer, H; Couper, David; Völzke, Henry; Campbell, Harry; Meitinger, Thomas; Uda, Manuela; C. M. Witteman, J.; M. Psaty, Bruce; Wichmann, H-Erich; B. Harris, T.; Kääb, Stefan; S. Siscovick, David; Jamshidi, Yalda; G. Uitterlinden, André; R. Folsom, A.; G. Larson, Martin; F. Wilson, James; W.J.H. Penninx, Brenda; Snieder, Harold; P. Pramstaller, Peter; M. van Duijn, Cornelia; G. Lakatta, Edward; B. Felix, Stephan; Guðnason, Vilmundur; Pfeufer, Arne; R. Heckbert, Susan; H. Stricker, Bruno; Boerwinkle, Eric; J. O’Donnell, Christopher

doi:10.1093/hmg/ddq303

Public

Genome-wide association analysis identifies multiple loci related to resting heart rate

Published in Human Molecular Genetics • Jul 16, 2010

Authors:

M. Eijgelsheim

Chris Newton-Cheh

N. Sotoodehnia

Abstract

Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that i...

Subject

Genome-wide association study

Biology

Genetic association

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