Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

Shintani, Mitsuyo; Ogawa, Yoshihiro; Ebihara, Ken; Aizawa‐Abe, Megumi; Miyanaga, Fumiko; Takaya, Kazuhiko; Hayashi, Tatsuya; Inoue, Gen; Hosoda, Kiminori; Kojima, Masayasu; Kangawa, Kenji; Nakao, Kazuwa

doi:10.2337/diabetes.50.2.227

Public

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

Published in Diabetes • Feb 1, 2001

Authors:

Mitsuyo Shintani

Yoshihiro Ogawa

Ken Ebihara

Abstract

Ghrelin, an endogenous ligand for growth hormone secretagogue (GHS) receptor originally isolated from the stomach, occurs in the hypothalamic arcuate nucleus and may play a role in energy homeostasis. Synthetic GHSs have activated the hypothalamic arcuate neurons containing neuropeptide Y (NPY), sug...

Subject

Orexigenic

Ghrelin

Internal medicine

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