Broadly targeted human cytomegalovirus-specific CD4 <b>+</b> and CD8 <b>+</b> T cells dominate the memory compartments of exposed subjects

Sylwester, Andrew; L. Mitchell, Bridget; B. Edgar, John; Taormina, Cara; Pelte, Christian; Ruchti, Franziska; R. Sleath, Paul; H. Grabstein, Kenneth; Hosken, Nancy; Kern, Florian; A. Nelson, Jay; J. Picker, Louis

doi:10.1084/jem.20050882

Public

Broadly targeted human cytomegalovirus-specific CD4 + and CD8 + T cells dominate the memory compartments of exposed subjects

Published in The Journal of Experimental Medicine • Sep 5, 2005

Authors:

Andrew Sylwester

Bridget L. Mitchell

John B. Edgar

Abstract

Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by a dynamic, life-long interaction in which host immune responses, particularly of T cells, restrain viral replication and prevent disease but do not eliminate the virus or preclude transmission. Because HCMV is amon...

Subject

Human cytomegalovirus

Biology

Immunodominance

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!