BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing

Domingo, Enric; Laiho, P; Ollikainen, M; Pinto, M; Wang, L; J French, A; Westra, J; Frebourg, T; Espín, E; Armengol, M; Hamelin, R; Yamamoto, H; M W Hofstra, R; Seruca, R; Lindblom, A; Peltomäki, P; N Thibodeau, S; A Aaltonen, L; Schwartz, S

doi:10.1136/jmg.2004.020651

Public

BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing

Published in Journal of Medical Genetics • Sep 1, 2004

Authors:

Enric Domingo

P Laiho

M Ollikainen

Abstract

BACKGROUND: According to the international criteria for hereditary non-polyposis colorectal cancer (HNPCC) diagnostics, cancer patients with a family history or early onset of colorectal tumours showing high microsatellite instability (MSI-H) should receive genetic counselling and be offered testing...

Subject

MSH2

MLH1

Germline mutation

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