Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in<i>Helicobacter pylori</i>–Infected Mice and Humans

Yanaka, Akinori; W. Fahey, Jed; Fukumoto, Atsushi; Nakayama, Mari; Inoue, Souta; Zhang, Songhua; Tauchi, Masafumi; Suzuki, Hideo; Hyodo, Ichinosuke; Yamamoto, Masayuki

doi:10.1158/1940-6207.capr-08-0192

Public

Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis inHelicobacter pylori–Infected Mice and Humans

Published in Cancer Prevention Research • Apr 1, 2009

Authors:

Akinori Yanaka

Jed W. Fahey

Atsushi Fukumoto

Abstract

The isothiocyanate sulforaphane [SF; 1-isothiocyanato-4(R)-methylsulfinylbutane] is abundant in broccoli sprouts in the form of its glucosinolate precursor (glucoraphanin). SF is powerfully bactericidal against Helicobacter pylori infections, which are strongly associated with the worldwide pandemic...

Subject

Sulforaphane

Helicobacter pylori

Glucoraphanin

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