Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networks.

Jarvela AM, Cheatle; L, Brubaker; A, Vedenko; A, Gupta; BA, Armitage; ML, Bulyk; VF, Hinman

doi:10.1093/molbev/msu213

Public

Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networks.

Shared by NobleBlocks on Jul 12, 2014 • 12:00 AM UTC

Authors:

Cheatle Jarvela AM

Brubaker L

Vedenko A

Abstract

Gene regulatory networks (GRNs) describe the progression of transcriptional states that take a single-celled zygote to a multicellular organism. It is well documented that GRNs can evolve extensively through mutations to cis-regulatory modules (CRMs). Transcription factor proteins that bind these CR...

Subject

Evolution

Transcription factors

Echinoderm

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