Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

Eugenia Miquilena-Colina, María; Lima-Cabello, Elena; Sánchez-Campos, Sonia; Victoria García-Mediavilla, María; Fernández-Bermejo, Miguel; Lozano-Rodríguez, Tamara; Vargas-Castrillón, Javier; Buqué, Xabier; Ochoa, Begoña; Aspichueta, Patricia; González-Gallego, Javier; García-Monzón, Carmelo

doi:10.1136/gut.2010.222844

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Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

Shared by NobleBlocks on Jan 26, 2011 • 12:00 AM UTC

Authors:

María Eugenia Miquilena-Colina

Elena Lima-Cabello

Sonia Sánchez-Campos

Abstract

Background Fatty acid translocase CD36 (FAT/CD36) mediates uptake and intracellular transport of long-chain fatty acids in diverse cell types. While the pathogenic role of FAT/CD36 in hepatic steatosis in rodents is well-defined, little is known about its significance in human liver diseases. Object...

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