Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

Bolli, Niccolò; Avet‐Loiseau, Hervé; C. Wedge, David; Van Loo, Peter; B. Alexandrov, Ludmil; Martincorena, Iñigo; J. Dawson, Kevin; Iorio, Francesco; Nik‐Zainal, Serena; R. Bignell, Graham; Hinton, Jonathan; Li, Yilong; M. C. Tubío, José; McLaren, Stuart; O' Meara, Sarah; P. Butler, Adam; W. Teague, Jon; Mudie, Laura; Anderson, Élizabeth; U. Rashid, Naim; Tai, Yu‐Tzu; A. Shammas, Masood; S. Sperling, Adam; Fulciniti, Mariateresa; G. Richardson, Paul; Parmigiani, Giovanni; Magrangeas, Florence; Minvielle, Stéphane; Moreau, Philippe; Attal, Michel; Façon, Thierry; Andrew Futreal, P.; C. Anderson, Kenneth; J. Campbell, Peter; C. Munshi, Nikhil

doi:10.1038/ncomms3997

Public

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

Published in Nature Communications • Jan 16, 2014

Authors:

Niccolò Bolli

Hervé Avet‐Loiseau

David C. Wedge

Abstract

Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse 84 myeloma samples. Most cases have a complex subclonal structure and show clusters of subc...

Subject

Biology

Somatic evolution in cancer

Copy-number variation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!