Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

Klein, Ulf; Tu, Yuhai; Stolovitzky, Gustavo; Mattioli, Michela; Cattoretti, Giorgio; Husson, Hervé; S. Freedman, Arnold; Inghirami, Giorgio; Cro, Lilla; Baldini, Luca; Neri, Antonino; Califano, Andrea; Dalla‐Favera, Riccardo

doi:10.1084/jem.194.11.1625

Public

Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

Published in The Journal of Experimental Medicine • Dec 3, 2001

Authors:

Ulf Klein

Yuhai Tu

Gustavo Stolovitzky

Abstract

B cell-derived chronic lymphocytic leukemia (B-CLL) represents a common malignancy whose cell derivation and pathogenesis are unknown. Recent studies have shown that >50% of CLLs display hypermutated immunoglobulin variable region (IgV) sequences and a more favorable prognosis, suggesting that they ...

Subject

Chronic lymphocytic leukemia

CD5

Biology

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