Strongly Enhanced Antitumor Activity of Trastuzumab and Pertuzumab Combination Treatment on HER2-Positive Human Xenograft Tumor Models

Scheuer, Werner; Friess, Thomas; Burtscher, Helmut; Bossenmaier, Birgit; Endl, Josef; Hasmann, Max

doi:10.1158/0008-5472.can-08-4597

Public

Strongly Enhanced Antitumor Activity of Trastuzumab and Pertuzumab Combination Treatment on HER2-Positive Human Xenograft Tumor Models

Published in Cancer Research • Nov 24, 2009

Authors:

Werner Scheuer

Thomas Friess

Helmut Burtscher

Abstract

The human epidermal growth factor receptor (HER) family plays an important role in cell survival and proliferation, and is implicated in oncogenesis. Overexpression of HER2 is associated with aggressive disease and poor prognosis. Trastuzumab is a humanized monoclonal antibody targeting HER2 and has...

Subject

Pertuzumab

Trastuzumab

Monoclonal antibody

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