FTO genotype is associated with phenotypic variability of body mass index.

Yang, Jian; J F Loos, Ruth; E Powell, Joseph; E Medland, Sarah; K Speliotes, Elizabeth; I Chasman, Daniel; M Rose, Lynda; Thorleifsson, Gudmar; Steinthorsdottir, Valgerdur; Mägi, Reedik; Waite, Lindsay; Vernon Smith, Albert; M Yerges-Armstrong, Laura; L Monda, Keri; Hadley, David; Mahajan, Anubha; Li, Guo; Kapur, Karen; Vitart, Veronique; E Huffman, Jennifer; R Wang, Sophie; Palmer, Cameron; Esko, Tõnu; Fischer, Krista; Hua Zhao, Jing; Demirkan, Ayşe; Isaacs, Aaron; F Feitosa, Mary; Luan, Jian'an; L Heard-Costa, Nancy; White, Charles; U Jackson, Anne; Preuss, Michael; Ziegler, Andreas; Eriksson, Joel; Kutalik, Zoltán; Frau, Francesca; M Nolte, Ilja; V Van Vliet-Ostaptchouk, Jana; Hottenga, Jouke-Jan; B Jacobs, Kevin; Verweij, Niek; Goel, Anuj; Medina-Gomez, Carolina; Estrada, Karol; Lynn Bragg-Gresham, Jennifer; Sanna, Serena; Sidore, Carlo; Tyrer, Jonathan; Teumer, Alexander

doi:10.1038/nature11401

Public

FTO genotype is associated with phenotypic variability of body mass index.

Shared by NobleBlocks on Oct 11, 2012 • 12:00 AM UTC

Authors:

Jian Yang

Ruth J F Loos

Joseph E Powell

Abstract

There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medici...

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