Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

Chandramohan, Vidyalakshmi; Bao, Xuhui; T. Keir, Stephen; N. Pegram, Charles; E. Szafranski, Scott; Piao, Hailan; J. Wikstrand, Carol; E. McLendon, Roger; Kuan, Chien‐Tsun; Pastan, Ira; D. Bigner, Darell

doi:10.1158/1078-0432.ccr-12-3891

Public

Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

Published in Clinical Cancer Research • Jul 15, 2013

Authors:

Vidyalakshmi Chandramohan

Xuhui Bao

Stephen T. Keir

Abstract

PURPOSE: The EGF receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is reactive with a 55-amino acid (AA) region present in th...

Subject

Flow cytometry

Cytotoxicity

Transfection

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