NLRP3 inflammasome–mediated neutrophil recruitment and hypernociception depend on leukotriene B<sub>4</sub>in a murine model of gout

A. Amaral, Flávio; V. Costa, Vivian; D. Tavares, Livia; Sachs, Daniela; M. Coelho, Fernanda; T. Fagundes, Caio; M. Soriani, Frederico; N. Silveira, Tatiana; D. Cunha, Larissa; S. Zamboni, Dario; Quesniaux, Valerie; S. Peres, Raphael; M. Cunha, Thiago; Q. Cunha, Fernando; Ryffel, Bernhard; G. Souza, Daniele; M. Teixeira, Mauro

doi:10.1002/art.33355

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NLRP3 inflammasome–mediated neutrophil recruitment and hypernociception depend on leukotriene B4in a murine model of gout

Shared by NobleBlocks on Jan 27, 2012 • 12:00 AM UTC

Authors:

Flávio A. Amaral

Vivian V. Costa

Livia D. Tavares

Abstract

Abstract Objective Deposition of monosodium urate monohydrate (MSU) crystals in the joints promotes an intense inflammatory response and joint dysfunction. This study evaluated the role of the NLRP3 inflammasome and 5‐lipoxygenase (5‐LOX)–derived leukotriene B 4 (LTB 4 ) in driving tissue inflammati...

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