NLRP3 inflammasome–mediated neutrophil recruitment and hypernociception depend on leukotriene B<sub>4</sub>in a murine model of gout

A. Amaral, Flávio; Vasconcelos Costa, Vivian; D. Tavares, Lívia; Sachs, Daniela; M. Coelho, Fernanda; T. Fagundes, Caio; Marianetti Soriani, Frederico; N. Silveira, Tatiana; D. Cunha, Larissa; S. Zamboni, Dario; Quesniaux, Valérie; Sanches Peres, Raphael; M. Cunha, Thiago; Q. Cunha, Fernando; Ryffel, Bernhard; G. Souza, Danielle; Martins Teixeira, Mauro

doi:10.1002/art.33355

Public

NLRP3 inflammasome–mediated neutrophil recruitment and hypernociception depend on leukotriene B4in a murine model of gout

Published in Arthritis & Rheumatism • Sep 28, 2011

Authors:

Flávio A. Amaral

Vivian Vasconcelos Costa

Lívia D. Tavares

Abstract

OBJECTIVE: Deposition of monosodium urate monohydrate (MSU) crystals in the joints promotes an intense inflammatory response and joint dysfunction. This study evaluated the role of the NLRP3 inflammasome and 5-lipoxygenase (5-LOX)-derived leukotriene B(4) (LTB(4) ) in driving tissue inflammation and...

Subject

Inflammasome

CXCL1

Chemistry

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