Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

S. Villadsen, Louise; Schuurman, Janine; J. Beurskens, Frank; Norman Dam, Tomas; Dagnæs‐Hansen, Frederik; Skov, Lone; Rygaard, Jørgen; M. Voorhorst‐Ogink, Marleen; F. Gerritsen, Arnout; A. van Dijk, Marc; W.H.I. Parren, Paul; Baadsgaard, Ole; G. J. van de Winkel, Jan

doi:10.1172/jci18986

Public

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

Published in Journal of Clinical Investigation • Nov 15, 2003

Authors:

Louise S. Villadsen

Janine Schuurman

Frank J. Beurskens

Abstract

Psoriasis is a chronic inflammatory disease of the skin characterized by epidermal hyperplasia, dermal angiogenesis, infiltration of activated T cells, and increased cytokine levels. One of these cytokines, IL-15, triggers inflammatory cell recruitment, angiogenesis, and production of other inflamma...

Subject

Psoriasis

Cytokine

Immunology

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