Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Takala‐Harrison, Shannon; G. Jacob, Christopher; Arze, Cesar; P. Cummings, Michael; C. Silva, Joana; M. Dondorp, Arjen; M. Fukuda, Mark; Tinh Hien, Tran; Mayxay, Mayfong; Noedl, Harald; Nosten, François; Phone Kyaw, Myat; Thanh Thuy Nhien, Nguyen; Imwong, Mallika; Bethell, Delia; Se, Youry; Lon, Chanthap; D. Tyner, Stuart; Saunders, David; Ariey, Frédéric; Mercereau‐Puijalon, Odile; Ménard, Didier; N. Newton, Paul; Khanthavong, Maniphone; Hongvanthong, Bouasy; Starzengrüber, Peter; Fuehrer, Hans‐Peter; Swoboda, Paul; Ali Khan, Wasif; Pyae Phyo, Aung; M. Nyunt, Myaing; Htut Nyunt, Myat; S. Brown, Tyler; Adams, Matthew; S. Pepin, Christopher; A. Bailey, Jason; C. Tan, John; T. Ferdig, Michael; G. Clark, Taane; Miotto, Olivo; MacInnis, Bronwyn; Kwiatkowski, Dominic; J. White, Nicholas; Ringwald, Pascal; V. Plowe, Christopher

doi:10.1093/infdis/jiu491

Public

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Published in The Journal of Infectious Diseases • Sep 1, 2014

Authors:

Shannon Takala‐Harrison

Christopher G. Jacob

Cesar Arze

Abstract

BACKGROUND: The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. METHODS: P. fal...

Subject

Plasmodium falciparum

Artemisinin

Biology

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