High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway

Yoshihara, Kosuke; Tsunoda, Tatsuhiko; Shigemizu, Daichi; Fujiwara, Hiroyuki; Hatae, Masayuki; Fujiwara, Hisaya; Masuzaki, Hideaki; Katabuchi, Hidetaka; Kawakami, Yosuke; Okamoto, Aikou; Nogawa, Takayoshi; Matsumura, Noriomi; Udagawa, Yasuhiro; Saito, Tsuyoshi; Itamochi, Hiroaki; Takano, Masashi; Miyagi, Etsuko; Sudo, Tamotsu; Ushijima, Kimio; Iwase, Haruko; Seki, Hiroyuki; Terao, Yasuhisa; Enomoto, Takayuki; Mikami, Mikio; Akazawa, Kohei; Tsuda, Hitoshi; Moriya, Takuya; Tajima, Atsushi; Inoue, Ituro; Tanaka, Kenichi

doi:10.1158/1078-0432.ccr-11-2725

Public

High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway

Published in Clinical Cancer Research • Jan 13, 2012

Authors:

Kosuke Yoshihara

Tatsuhiko Tsunoda

Daichi Shigemizu

Abstract

PURPOSE: High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system based on a gene expression signature for predicting overall survival, leading to suggesting novel therapeuti...

Subject

Serous fluid

Ovarian cancer

Gene signature

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