Drotrecogin Alfa (Activated) in Adults with Septic Shock

Marco Ranieri, V.; Thompson, Bruce; S. Barie, Philip; Dhainaut, Jean-François; S. Douglas, Ivor; Finfer, Simon; Gårdlund, Bengt; C. Marshall, John; Rhodes, Andrew; Artigas, Antonio; Payen, Didier; Tenhunen, Jyrki; R. Al‐Khalidi, Hussein; P. Thompson, Vivian; Janes, Jonathan; L. Macias, William; Vangerow, Burkhard; D. Williams, Mark

doi:10.1056/nejmoa1202290

Public

Drotrecogin Alfa (Activated) in Adults with Septic Shock

Published in New England Journal of Medicine • May 31, 2012

Authors:

V. Marco Ranieri

Bruce Thompson

Philip S. Barie

Abstract

BACKGROUND: There have been conflicting reports on the efficacy of recombinant human activated protein C, or drotrecogin alfa (activated) (DrotAA), for the treatment of patients with septic shock. METHODS: In this randomized, double-blind, placebo-controlled, multicenter trial, we assigned 1697 pati...

Subject

Drotrecogin alfa

Medicine

Septic shock

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